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The top five worst NBA losses of all time are listed. The Portland Trailblazers lost to the OKC Thunder by 62 points. The Golden State Warriors lost to the Los Angeles Lakers by 63 points in 1972. The Trailblazers lost to the Indiana Pacers by 65 points in 1998. The Miami Heat lost to the Cleveland Cavaliers by 68 points. The OKC Thunder lost to the Memphis Grizzlies by 73 points. we got the top five absolute worst nba losses of all time starting off at number five we have the portland trailblazers versus the okc thunder where the thunder won by 62 points this season now at number four we have the golden state warriors versus the los angeles lakers where the lakers won the game by 63 points in 1972 now at number three we have the trailblazers again versus the indiana pacers where the blazers ended up losing in 1998 by 65 with a score of 124 to 59 then at number two we have the miami heat versus the cleveland cavaliers which the calves handed miami a 68 point loss in that game and at number one we have the thunder versus the memphis grizzlies and a 73 point loss where the grizzlies dominated in that game