Shivangi podcast audio

The speaker discusses the bacterium Clipseria pneumoniae, which is usually harmless in the intestines but can cause infections in the lungs and bloodstream. Antibiotics such as benzoyl penicillin and tetracycline are not effective against this bacterium, while ampicillin is resistant and gentamicin is sensitive. Ceftazidime is also sensitive, but there is insufficient evidence for ticarcidin and nystatin. The increase in antibiotic-resistant bacteria highlights the need for new drugs and vaccines, as well as increased research and awareness in this area. Hi everyone, I welcome you all to another episode on microbiology where we go deep into enchanting facts about microbiology that directly or indirectly is related to our life. I am Shubhangi and today we will be talking about a specific bacterium, Clipseria pneumoniae and what diseases it causes that is harmful to us. So do you know what Clipseria pneumoniae is? It is a type of bacteria usually found in the nature. It is found in our intestines in the human body where they reside without causing any harm. But if they get in parts of our body like lungs or the bloodstream when we are already sick, it can be harmful and cause acute infections such as pneumoniae or infections in the bloodstream. So we now move on to part 2 where according to the European Committee on Antimicrobial Susceptibility Testing, UCAS, many antibiotics have been tested against pneumoniae. So for benzoyl penicillin, tetracycline, erythromycin and chloramphenicol sadly there has been very insufficient evidence about this antibiotic and it says that the antibiotic is not a good treatment option. So susceptibility testing is also not recommended for this antibiotic as it is not suitable for treating infections caused by this microbe. Now as we move on to ampicillin, for this antibiotic, K pneumoniae is considered resistant if the zone of inhibition is less than 14 mm and sensitive if it is 14 mm or greater. So according to my calculation when I actually took out the mean value for zone of inhibition it was 5.421 mm which means that the microbe is resistant to ampicillin. Now if we talk about gentamicin, so for this antibiotic, K pneumoniae is considered resistant if the inhibition zone is less than 17 mm and sensitive if it is 17 mm or greater. So the mean value that I got after calculation was 17.5 mm which means that the microbe is sensitive to gentamicin. Now if we talk about ceftazidime, so for ceftazidime the microbe is considered resistant if the zone of inhibition is less than 19 mm and sensitive if it is 22 mm or greater. So the value for mean zone of inhibition that I got was 32.20 mm which means that the microbe is sensitive to ceftazidime. But again for ticarcidin and nystatin there was no sufficient evidence. So what are future antimicrobial therapies? Since we all know that K pneumoniae is seen to be an antibiotic resistant bacteria and there is a huge increase in the number of antibiotic resistant bacteria, it actually puts more focus on the fact that new drugs and vaccines are supposed to be made. We also need to put more focus on research and development in this area. Hospitals should rely on new antibiotics with new combinations and in communities people should be aware of what they are consuming. So this is all for today and I hope you enjoyed knowing more about microorganisms. I would like to take a leave. Thank you. Have a great day ahead.