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Streptococcus pyogenes can cause severe conditions like impetigo, a highly contagious rash in children, and streptococcal toxic shock syndrome, a blood infection that can lead to tissue death and even loss of limbs if not treated or detected. Some interesting facts about Streptococcus pyogenes is that it can cause something as severe as impetigo, which is a rash that is incredibly contagious and is mainly contracted by young children. It can also cause streptococcal toxic shock syndrome, which is a blood infection that can cause tissue necrosis, which is tissue death, and extremity loss if left untreated or undetected.